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KMID : 0363319900110020094
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Journal of Korean Oriental Internal Medicine
1990 Volume.11 No. 2 p.94 ~ p.103
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Effects of Ga Gam Sam Kee Tang Water Extract on the Plasma Cortisol Concentration and Arterial Blood PCO₂PO₂ in the Rabbit
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Lee Seung-Woo
Han Sang-Hwan
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Abstract
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To evaluate effects of Ga Gam Sam Kee Tang(GGSKT) water extract on the plasma cortisol concentration and arterial blood PCO₂PO₂ in the rabbit. The results obtained were as follows : 1. Intravenous administration of GGSKT water at the dose of 0.2 ㎖/㎏ remarkably increased plasma cortisol concentration from 1 to 2 hours. 2. Oral administration of GGSKT water extract at the dose of 10㎖/㎏ significantly decreased plasma cortisol concentration on 3 hours. 3. Intravenous administration of GGSKT water extract at the dose of 0.4㎖/㎏ remarkably decreased arterial blood PO₂ on 2 hours. 4. Oral administration of GGSKT water extract at the dose of 1.0㎖/㎏ significantly decreased arterial blood PO₂ on 2 hours and remarkably increased on 4 hours. 5. Intravenous administration of GGSKT water extract at the dose of 0.2㎖/㎏ remarkably increased arterial blood PCO₂ on 4 hours. 6. Oral administration of GGSKT water extract at the dose of 2.0㎖/㎏ significantly decreased arterial blood PCO₂ from 1 to 2 hours. These results suggest that therapeutic action of GGSKT water extract for athma may be related with the increment of plasma cortisol concentration and the decrease of arterial blood PCO₂
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